Chinese researchers have identified a new bat coronavirus, HKU5-CoV-2, capable of infecting human cells, reigniting discussions on zoonotic diseases and pandemic preparedness. Led by virologist Shi Zhengli, the study was published in Cell and highlights the virus’s similarities to SARS-CoV-2.
A descendant of the HKU5 virus found in Japanese pipistrelle bats, HKU5-CoV-2 belongs to the merbecovirus subgenus, which includes MERS. Notably, it features a furin cleavage site that aids in human cell invasion. While lab tests show it can infect cells with high ACE2 expression, researchers emphasize that its human infection potential is far lower than SARS-CoV-2.
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Experts, including Michael Osterholm, downplay alarmist concerns, citing global immunity improvements post-COVID-19. Studies from the University of Washington and Wuhan University further indicate that the virus does not efficiently bind to human ACE2 receptors. Encouragingly, existing monoclonal antibodies and antiviral drugs show promise in countering HKU5-CoV-2 if needed.
Amid ongoing scrutiny of China’s viral research, Shi Zhengli’s team remains focused on early detection and prevention. While continued monitoring is essential, experts agree that HKU5-CoV-2 does not pose an immediate threat, reinforcing the importance of preparedness without unnecessary panic.
