A recent Australian study has found that women are genetically at higher risk of depression than men. Researchers say the findings could transform how the disorder is diagnosed and treated.
Scientists analyzed the DNA of nearly 200,000 people with depression to identify genetic markers linked to the condition. They discovered that women carried almost twice as many markers associated with depression compared to men.
Jodi Thomas of the Berghofer Medical Research Institute, which led the study, said, “The genetic component to depression is larger in females compared to males.” The research highlights the importance of understanding sex-based differences in the disorder.
The study identified about 13,000 genetic markers related to depression in women, while men had roughly 7,000 markers. Some markers may affect hormone regulation and metabolism, which could explain why women often experience symptoms such as weight changes or low energy levels during depression.
Co-researcher Brittany Mitchell noted that these findings could lead to more personalized treatments for women, addressing the historical focus on men in depression research and drug development. She emphasized that understanding genetic differences is crucial to improving outcomes for both sexes.
The study, published in Nature Communications, is considered one of the largest genetic studies on depression. Researchers say it provides the clearest evidence yet of biological differences in how the disorder affects men and women.
Depression, also known as major depressive disorder, affects over 300 million people worldwide, according to the World Health Organization. Experts say the study underscores the need for inclusive research and treatment strategies that consider gender-specific factors.
The findings mark an important step toward personalized mental health care, offering hope for better management of depression and improved support for women affected by the condition.
In other related news also read After years of depression, Pakistani snooker player commits suicide.
